Golgicide A
10mM in DMSO
- Product Code: 190169
CAS:
1139889-93-2
| Molecular Weight: | 284.3 g./mol | Molecular Formula: | C₁₇H₁₄F₂N₂ |
|---|---|---|---|
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| Density: | Storage Condition: | -20°C |
Product Description:
Golgicide A is primarily used as a selective inhibitor of the ADP-ribosylation factor 1 (Arf1) guanine nucleotide exchange factor (GEF), specifically targeting the Golgi-specific GEF called GBF1. This compound is widely applied in cell biology research to study the function and dynamics of the Golgi apparatus and its role in intracellular protein trafficking.
By inhibiting GBF1, Golgicide A disrupts the activation of Arf1, which leads to the disassembly of COPI-coated vesicles. This disruption blocks anterograde and retrograde transport between the endoplasmic reticulum (ER) and the Golgi, making it a valuable tool for investigating secretory pathway mechanisms.
Researchers use Golgicide A to probe processes such as protein secretion, glycosylation, and organelle integrity. It has also been employed in studies examining viral replication, as many viruses depend on the host secretory machinery for proper assembly and egress. The specificity of Golgicide A allows for acute and reversible manipulation of Golgi function, enabling precise temporal control in experimental settings.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿6,480.00 |
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Golgicide A
Golgicide A is primarily used as a selective inhibitor of the ADP-ribosylation factor 1 (Arf1) guanine nucleotide exchange factor (GEF), specifically targeting the Golgi-specific GEF called GBF1. This compound is widely applied in cell biology research to study the function and dynamics of the Golgi apparatus and its role in intracellular protein trafficking.
By inhibiting GBF1, Golgicide A disrupts the activation of Arf1, which leads to the disassembly of COPI-coated vesicles. This disruption blocks anterograde and retrograde transport between the endoplasmic reticulum (ER) and the Golgi, making it a valuable tool for investigating secretory pathway mechanisms.
Researchers use Golgicide A to probe processes such as protein secretion, glycosylation, and organelle integrity. It has also been employed in studies examining viral replication, as many viruses depend on the host secretory machinery for proper assembly and egress. The specificity of Golgicide A allows for acute and reversible manipulation of Golgi function, enabling precise temporal control in experimental settings.
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