GSK343
2mM in DMSO
- Product Code: 190203
CAS:
1346704-33-3
| Molecular Weight: | 541.69 g./mol | Molecular Formula: | C₃₁H₃₉N₇O₂ |
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| Density: | Storage Condition: | -20°C |
Product Description:
GSK343 is a potent and selective inhibitor of the enhancer of zeste homolog 2 (EZH2), which is a histone methyltransferase involved in gene silencing through methylation of histone H3 at lysine 27 (H3K27me3). Due to its inhibitory action, GSK343 is widely used in epigenetic research to study the role of EZH2 in cellular processes such as differentiation, proliferation, and cancer progression.
It has shown significant utility in oncology-related studies, particularly in models of cancers where EZH2 is overexpressed or mutated, including lymphomas, breast cancer, and certain solid tumors. By inhibiting EZH2 activity, GSK343 helps reactivate tumor suppressor genes that have been silenced, making it a valuable tool for understanding epigenetic regulation in disease.
In preclinical research, GSK343 is used to assess the therapeutic potential of EZH2 inhibition, helping to validate targets and guide the development of new cancer therapies. Its selectivity makes it suitable for cell-based assays and in vivo studies where precise modulation of epigenetic markers is required.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿4,480.00 |
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GSK343
GSK343 is a potent and selective inhibitor of the enhancer of zeste homolog 2 (EZH2), which is a histone methyltransferase involved in gene silencing through methylation of histone H3 at lysine 27 (H3K27me3). Due to its inhibitory action, GSK343 is widely used in epigenetic research to study the role of EZH2 in cellular processes such as differentiation, proliferation, and cancer progression.
It has shown significant utility in oncology-related studies, particularly in models of cancers where EZH2 is overexpressed or mutated, including lymphomas, breast cancer, and certain solid tumors. By inhibiting EZH2 activity, GSK343 helps reactivate tumor suppressor genes that have been silenced, making it a valuable tool for understanding epigenetic regulation in disease.
In preclinical research, GSK343 is used to assess the therapeutic potential of EZH2 inhibition, helping to validate targets and guide the development of new cancer therapies. Its selectivity makes it suitable for cell-based assays and in vivo studies where precise modulation of epigenetic markers is required.
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