GSK126
2mM in DMSO
- Product Code: 190248
CAS:
1346574-57-9
| Molecular Weight: | 526.67 g./mol | Molecular Formula: | C₃₁H₃₈N₆O₂ |
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| Density: | Storage Condition: | -20°C, Sealed, Dry |
Product Description:
GSK126 is primarily used in epigenetic research as a potent and selective inhibitor of the enzyme EZH2 (enhancer of zeste homolog 2). EZH2 is a histone methyltransferase that catalyzes the addition of methyl groups to lysine 27 on histone H3 (H3K27me3), a modification associated with gene silencing. Overactivity of EZH2 is linked to several types of cancers, including lymphoma, breast, and prostate cancer, due to the repression of tumor suppressor genes.
GSK126 is widely applied in preclinical studies to investigate the role of EZH2 inhibition in cancer cell proliferation, apoptosis, and differentiation. It has shown antitumor activity in cell lines and animal models with EZH2 gain-of-function mutations. Researchers use GSK126 to probe epigenetic mechanisms and evaluate the therapeutic potential of targeting the PRC2 complex in oncology.
In addition to cancer research, GSK126 is used to study stem cell differentiation and developmental biology, where EZH2-mediated gene regulation plays a critical role. Its selectivity makes it a valuable tool compound for validating EZH2 as a drug target and for guiding the development of clinical-stage inhibitors.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿18,900.00 |
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GSK126
GSK126 is primarily used in epigenetic research as a potent and selective inhibitor of the enzyme EZH2 (enhancer of zeste homolog 2). EZH2 is a histone methyltransferase that catalyzes the addition of methyl groups to lysine 27 on histone H3 (H3K27me3), a modification associated with gene silencing. Overactivity of EZH2 is linked to several types of cancers, including lymphoma, breast, and prostate cancer, due to the repression of tumor suppressor genes.
GSK126 is widely applied in preclinical studies to investigate the role of EZH2 inhibition in cancer cell proliferation, apoptosis, and differentiation. It has shown antitumor activity in cell lines and animal models with EZH2 gain-of-function mutations. Researchers use GSK126 to probe epigenetic mechanisms and evaluate the therapeutic potential of targeting the PRC2 complex in oncology.
In addition to cancer research, GSK126 is used to study stem cell differentiation and developmental biology, where EZH2-mediated gene regulation plays a critical role. Its selectivity makes it a valuable tool compound for validating EZH2 as a drug target and for guiding the development of clinical-stage inhibitors.
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