GSK3145095
10mM in DMSO
- Product Code: 190282
CAS:
1622849-43-7
| Molecular Weight: | 397.38 g./mol | Molecular Formula: | C₂₀H₁₇F₂N₅O₂ |
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| Density: | Storage Condition: | -20°C |
Product Description:
GSK3145095 is an investigational small molecule inhibitor targeting the enzyme arginase, which plays a role in modulating immune responses in the tumor microenvironment. By inhibiting arginase, this compound helps restore T-cell function, which can be suppressed in cancer settings due to arginine depletion. This mechanism supports enhanced anti-tumor immunity, making GSK3145095 a potential candidate for cancer immunotherapy. It has been evaluated in clinical trials, particularly for solid tumors, to assess its safety and efficacy either as a monotherapy or in combination with other immune checkpoint inhibitors like anti-PD-1 agents. The primary therapeutic focus is on leveraging the compound’s immunomodulatory effects to improve patient response to cancer treatment.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿6,840.00 |
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GSK3145095
GSK3145095 is an investigational small molecule inhibitor targeting the enzyme arginase, which plays a role in modulating immune responses in the tumor microenvironment. By inhibiting arginase, this compound helps restore T-cell function, which can be suppressed in cancer settings due to arginine depletion. This mechanism supports enhanced anti-tumor immunity, making GSK3145095 a potential candidate for cancer immunotherapy. It has been evaluated in clinical trials, particularly for solid tumors, to assess its safety and efficacy either as a monotherapy or in combination with other immune checkpoint inhibitors like anti-PD-1 agents. The primary therapeutic focus is on leveraging the compound’s immunomodulatory effects to improve patient response to cancer treatment.
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