GNE-493
10mM in DMSO
- Product Code: 190294
CAS:
1033735-94-2
| Molecular Weight: | 372.44 g./mol | Molecular Formula: | C₁₇H₂₀N₆O₂S |
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| Density: | Storage Condition: | -20°C |
Product Description:
GNE-493 is a potent and selective inhibitor of the kinase enzyme LRRK2 (leucine-rich repeat kinase 2), which is implicated in the pathogenesis of Parkinson’s disease. It is primarily used in research settings to study the role of LRRK2 in cellular models and animal studies related to neurodegeneration. By inhibiting LRRK2 activity, GNE-493 helps reduce the abnormal phosphorylation of downstream substrates such as Rab GTPases, which are involved in vesicle trafficking and lysosomal function. This makes GNE-493 a valuable tool compound for validating LRRK2 as a therapeutic target and for assessing the potential of kinase inhibition in slowing or modifying disease progression in Parkinson’s models. Its high selectivity and favorable pharmacokinetic properties support its use in preclinical studies aimed at understanding the biological consequences of LRRK2 inhibition.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿7,060.00 |
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GNE-493
GNE-493 is a potent and selective inhibitor of the kinase enzyme LRRK2 (leucine-rich repeat kinase 2), which is implicated in the pathogenesis of Parkinson’s disease. It is primarily used in research settings to study the role of LRRK2 in cellular models and animal studies related to neurodegeneration. By inhibiting LRRK2 activity, GNE-493 helps reduce the abnormal phosphorylation of downstream substrates such as Rab GTPases, which are involved in vesicle trafficking and lysosomal function. This makes GNE-493 a valuable tool compound for validating LRRK2 as a therapeutic target and for assessing the potential of kinase inhibition in slowing or modifying disease progression in Parkinson’s models. Its high selectivity and favorable pharmacokinetic properties support its use in preclinical studies aimed at understanding the biological consequences of LRRK2 inhibition.
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