Gimeracil
99%
- Product Code: 190436
Alias:
Gimepyrimidine; Gimost; 4-hydroxy-5-chloro-2-(1H)pyridone
CAS:
103766-25-2
| Molecular Weight: | 145.54 g./mol | Molecular Formula: | C₅H₄ClNO₂ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD08458352 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | Room temperature, sealed |
Product Description:
Used in combination chemotherapy, particularly in the anticancer drug S-1, where it enhances the efficacy of 5-fluorouracil (5-FU) by inhibiting its degradation. Gimeracil acts as a potent inhibitor of dihydropyrimidine dehydrogenase (DPD), the enzyme responsible for breaking down 5-FU in the body. By blocking this enzyme, it prolongs the half-life and increases the concentration of 5-FU, allowing for sustained antitumor activity at lower doses. This results in improved therapeutic outcomes and reduced side effects in the treatment of cancers such as gastric, colorectal, and head and neck cancers. Its role is purely supportive, optimizing the pharmacokinetics of the active cytotoxic agent without direct antineoplastic action.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 5.000 G | 10-20 days | ฿310.00 |
+
-
|
| 25.000 G | 10-20 days | ฿1,220.00 |
+
-
|
Gimeracil
Used in combination chemotherapy, particularly in the anticancer drug S-1, where it enhances the efficacy of 5-fluorouracil (5-FU) by inhibiting its degradation. Gimeracil acts as a potent inhibitor of dihydropyrimidine dehydrogenase (DPD), the enzyme responsible for breaking down 5-FU in the body. By blocking this enzyme, it prolongs the half-life and increases the concentration of 5-FU, allowing for sustained antitumor activity at lower doses. This results in improved therapeutic outcomes and reduced side effects in the treatment of cancers such as gastric, colorectal, and head and neck cancers. Its role is purely supportive, optimizing the pharmacokinetics of the active cytotoxic agent without direct antineoplastic action.
| Mechanism | - |
| Appearance | - |
| Longevity | - |
| Strength | - |
| Storage | - |
| Shelf Life | - |
| Allergen(s) | - |
| Dosage (Range) | - |
| Recommended Dosage | - |
| Dosage (Per Day) | - |
| Recommended Dosage (Per Day) | - |
| Mix Method | - |
| Heat Resistance | - |
| Stable in pH range | - |
| Solubility | - |
| Product Types | - |
| INCI | - |
Purchase History for
Loading purchase history...
Cart
No products
Subtotal:
฿0.00
฿0.00
Total :