Gliotoxin
95%
- Product Code: 190554
CAS:
67-99-2
| Molecular Weight: | 326.391 g./mol | Molecular Formula: | C₁₃H₁₄N₂O₄S₂ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00058534 | |
| Melting Point: | Boiling Point: | 699.7±55.0℃ at 760 mmHg | |
| Density: | 1.8±0.1g/ml | Storage Condition: | Room temperature, dry, away from light |
Product Description:
Gliotoxin is primarily known for its immunosuppressive properties, making it relevant in the study of immune system modulation. It has been investigated for its ability to inhibit the activation of T-cells and the production of reactive oxygen species in macrophages, which can suppress inflammatory responses. This makes it a compound of interest in autoimmune disease research and transplant medicine where immune suppression is required.
Additionally, gliotoxin exhibits strong antifungal and antimicrobial activities, suggesting potential use in controlling microbial growth, especially in targeted therapeutic contexts. However, its toxicity limits its direct clinical application.
It also plays a role in cancer research due to its ability to induce apoptosis in various tumor cell lines through the generation of oxidative stress and inhibition of the NF-κB signaling pathway, a key regulator of cell survival and inflammation.
Despite its toxic profile, gliotoxin serves as a valuable tool in biomedical research for understanding cellular redox balance, immune evasion mechanisms, and fungal pathogenesis.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.005 G | 10-20 days | ฿82,990.00 |
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Gliotoxin
Gliotoxin is primarily known for its immunosuppressive properties, making it relevant in the study of immune system modulation. It has been investigated for its ability to inhibit the activation of T-cells and the production of reactive oxygen species in macrophages, which can suppress inflammatory responses. This makes it a compound of interest in autoimmune disease research and transplant medicine where immune suppression is required.
Additionally, gliotoxin exhibits strong antifungal and antimicrobial activities, suggesting potential use in controlling microbial growth, especially in targeted therapeutic contexts. However, its toxicity limits its direct clinical application.
It also plays a role in cancer research due to its ability to induce apoptosis in various tumor cell lines through the generation of oxidative stress and inhibition of the NF-κB signaling pathway, a key regulator of cell survival and inflammation.
Despite its toxic profile, gliotoxin serves as a valuable tool in biomedical research for understanding cellular redox balance, immune evasion mechanisms, and fungal pathogenesis.
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