Gelomulide A
98%
- Product Code: 190652
CAS:
122537-59-1
| Molecular Weight: | 374.471 g./mol | Molecular Formula: | C₂₂H₃₀O₅ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | 240℃ | Boiling Point: | 508.0±50.0℃ at 760 mmHg |
| Density: | 1.2±0.1g/ml | Storage Condition: | Room temperature |
Product Description:
Gelomulide A is primarily studied for its potential anticancer properties. It functions as a potent inhibitor of histone deacetylases (HDACs), particularly HDAC6, which plays a key role in the regulation of protein acetylation and cellular processes such as cell division, apoptosis, and DNA repair. By inhibiting HDAC6, Gelomulide A induces accumulation of acetylated proteins, leading to cell cycle arrest and apoptosis in various cancer cell lines.
Its high selectivity for HDAC6 makes it a valuable tool in oncology research, especially in studies focused on multiple myeloma, leukemia, and other hematological malignancies. Due to its natural origin and strong bioactivity, it is also used as a lead compound in the development of new HDAC-targeted therapeutics. Additionally, Gelomulide A serves as a molecular probe to investigate the biological roles of HDAC6 in cellular models, helping to elucidate pathways involved in tumor progression and resistance to therapy.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.005 G | 10-20 days | ฿41,600.00 |
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Gelomulide A
Gelomulide A is primarily studied for its potential anticancer properties. It functions as a potent inhibitor of histone deacetylases (HDACs), particularly HDAC6, which plays a key role in the regulation of protein acetylation and cellular processes such as cell division, apoptosis, and DNA repair. By inhibiting HDAC6, Gelomulide A induces accumulation of acetylated proteins, leading to cell cycle arrest and apoptosis in various cancer cell lines.
Its high selectivity for HDAC6 makes it a valuable tool in oncology research, especially in studies focused on multiple myeloma, leukemia, and other hematological malignancies. Due to its natural origin and strong bioactivity, it is also used as a lead compound in the development of new HDAC-targeted therapeutics. Additionally, Gelomulide A serves as a molecular probe to investigate the biological roles of HDAC6 in cellular models, helping to elucidate pathways involved in tumor progression and resistance to therapy.
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