4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-(trifluoromethyl)-1H-indazole
97%
- Product Code: 191182
CAS:
1186334-80-4
| Molecular Weight: | 312.095 g./mol | Molecular Formula: | C₁₄H₁₆BF₃N₂O₂ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD27993180 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | Room temperature |
Product Description:
Widely used in Suzuki-Miyaura cross-coupling reactions, this compound serves as a key boronic ester reagent for constructing carbon-carbon bonds in medicinal chemistry and drug development. Its indazole core with a trifluoromethyl group enhances binding selectivity and metabolic stability, making it valuable in synthesizing bioactive molecules, particularly kinase inhibitors and other pharmaceuticals targeting cancer and inflammatory diseases. The boronate ester functionality allows for mild, efficient coupling with aryl or heteroaryl halides, enabling rapid diversification of molecular structures during lead optimization. It is also employed in the preparation of labeled compounds for imaging and tracer studies due to its stability and reactivity profile.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 G | 10-20 days | ฿26,880.00 |
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4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-(trifluoromethyl)-1H-indazole
Widely used in Suzuki-Miyaura cross-coupling reactions, this compound serves as a key boronic ester reagent for constructing carbon-carbon bonds in medicinal chemistry and drug development. Its indazole core with a trifluoromethyl group enhances binding selectivity and metabolic stability, making it valuable in synthesizing bioactive molecules, particularly kinase inhibitors and other pharmaceuticals targeting cancer and inflammatory diseases. The boronate ester functionality allows for mild, efficient coupling with aryl or heteroaryl halides, enabling rapid diversification of molecular structures during lead optimization. It is also employed in the preparation of labeled compounds for imaging and tracer studies due to its stability and reactivity profile.
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