(2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methanol
97%
- Product Code: 191208
CAS:
160514-13-6
| Molecular Weight: | 252.27 g./mol | Molecular Formula: | C₁₄H₁₂N₄O |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD29920703 | |
| Melting Point: | Boiling Point: | 527.6±60.0 °C(Predicted) | |
| Density: | 1.315±0.06 g/cm3(Predicted) | Storage Condition: | 2-8°C, Inert Gas |
Product Description:
Used primarily as an intermediate in the synthesis of angiotensin II receptor antagonists, such as valsartan and related sartan-class antihypertensive drugs. Its tetrazole group mimics the carboxylate group in angiotensin II, enabling effective binding to the AT1 receptor. The biphenyl methanol structure provides a rigid scaffold that enhances selectivity and potency. It is valuable in pharmaceutical development for creating potent, orally active agents that lower blood pressure by blocking vasoconstriction and aldosterone release.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 G | 10-20 days | ฿6,010.00 |
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| 1.000 G | 10-20 days | ฿27,510.00 |
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(2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methanol
Used primarily as an intermediate in the synthesis of angiotensin II receptor antagonists, such as valsartan and related sartan-class antihypertensive drugs. Its tetrazole group mimics the carboxylate group in angiotensin II, enabling effective binding to the AT1 receptor. The biphenyl methanol structure provides a rigid scaffold that enhances selectivity and potency. It is valuable in pharmaceutical development for creating potent, orally active agents that lower blood pressure by blocking vasoconstriction and aldosterone release.
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