1H-Tetrazole, 5-(ethylsulfonyl)-1-phenyl-
≥95%
- Product Code: 191973
CAS:
3206-46-0
| Molecular Weight: | 238.2663 g./mol | Molecular Formula: | C₉H₁₀N₄O₂S |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00447901 | |
| Melting Point: | 73-74 °C | Boiling Point: | 435.3±28.0 °C(Predicted) |
| Density: | 1.44±0.1 g/cm3(Predicted) | Storage Condition: | 2-8°C |
Product Description:
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and irbesartan. The tetrazole ring with the ethylsulfonyl and phenyl substituents enhances metabolic stability and binding affinity to the AT1 receptor. It is also employed in medicinal chemistry for developing bioisosteres of carboxylic acids due to the tetrazole group’s ability to mimic carboxylate anions while improving lipophilicity and oral bioavailability. Additionally, this compound finds use in the preparation of agrochemicals and functional materials where nitrogen-rich heterocycles are required for activity or structural properties.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.010 G | 10-20 days | ฿1,600.00 |
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1H-Tetrazole, 5-(ethylsulfonyl)-1-phenyl-
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and irbesartan. The tetrazole ring with the ethylsulfonyl and phenyl substituents enhances metabolic stability and binding affinity to the AT1 receptor. It is also employed in medicinal chemistry for developing bioisosteres of carboxylic acids due to the tetrazole group’s ability to mimic carboxylate anions while improving lipophilicity and oral bioavailability. Additionally, this compound finds use in the preparation of agrochemicals and functional materials where nitrogen-rich heterocycles are required for activity or structural properties.
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