tert-Butyl 5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
95%
- Product Code: 192369
CAS:
1443377-15-8
| Molecular Weight: | 361.22 g./mol | Molecular Formula: | C₁₉H₂₅BFNO₄ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD28717131 | |
| Melting Point: | Boiling Point: | 457.4±48.0 °C(Predicted) | |
| Density: | 1.13±0.1 g/cm3(Predicted) | Storage Condition: | -20°C, Sealed, Inert Gas |
Product Description:
Used as an intermediate in palladium-catalyzed cross-coupling reactions, particularly in the synthesis of biologically active indole derivatives. The boronate ester group enables Suzuki-Miyaura coupling, allowing the introduction of various aryl or heteroaryl groups at the 2-position of the indole ring. The tert-butyl carbamate (Boc) group protects the indole nitrogen during reactions and can be removed under mild acidic conditions when needed. This compound is valuable in medicinal chemistry for constructing complex molecules, especially in the development of pharmaceuticals targeting neurological disorders, inflammation, and cancer. Its fluorinated indole core enhances binding selectivity and metabolic stability in final drug candidates.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1.000 G | 10-20 days | ฿3,940.00 |
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| 5.000 G | 10-20 days | ฿14,880.00 |
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tert-Butyl 5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
Used as an intermediate in palladium-catalyzed cross-coupling reactions, particularly in the synthesis of biologically active indole derivatives. The boronate ester group enables Suzuki-Miyaura coupling, allowing the introduction of various aryl or heteroaryl groups at the 2-position of the indole ring. The tert-butyl carbamate (Boc) group protects the indole nitrogen during reactions and can be removed under mild acidic conditions when needed. This compound is valuable in medicinal chemistry for constructing complex molecules, especially in the development of pharmaceuticals targeting neurological disorders, inflammation, and cancer. Its fluorinated indole core enhances binding selectivity and metabolic stability in final drug candidates.
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