4-Fluoro-1H-indazole-6-carbonitrile
≥98%
- Product Code: 192710
CAS:
1082041-49-3
| Molecular Weight: | 161.14 g./mol | Molecular Formula: | C₈H₄FN₃ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD11007865 | |
| Melting Point: | Boiling Point: | 364.2±22.0 °C(Predicted) | |
| Density: | 1.44±0.1 g/cm3(Predicted) | Storage Condition: | 2-8°C, sealed, dry |
Product Description:
Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors for cancer treatment. It serves as a building block in medicinal chemistry due to the presence of both the nitrile and indazole functionalities, which are known to enhance binding affinity to biological targets. Commonly employed in the preparation of potent and selective inhibitors targeting enzymes such as PDE10A and FLT3, which are implicated in neurological disorders and leukemia. Its fluorinated structure improves metabolic stability and membrane permeability, making it valuable in optimizing drug candidates for in vivo efficacy. Also utilized in agrochemical research for designing bioactive molecules with enhanced activity and selectivity.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.250 G | 10-20 days | ฿27,990.00 |
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| 1.000 G | 10-20 days | ฿34,990.00 |
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4-Fluoro-1H-indazole-6-carbonitrile
Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors for cancer treatment. It serves as a building block in medicinal chemistry due to the presence of both the nitrile and indazole functionalities, which are known to enhance binding affinity to biological targets. Commonly employed in the preparation of potent and selective inhibitors targeting enzymes such as PDE10A and FLT3, which are implicated in neurological disorders and leukemia. Its fluorinated structure improves metabolic stability and membrane permeability, making it valuable in optimizing drug candidates for in vivo efficacy. Also utilized in agrochemical research for designing bioactive molecules with enhanced activity and selectivity.
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