4-([1,1'-Biphenyl]-4-yl(phenyl)methyl)-1H-imidazole
98%
- Product Code: 192724
CAS:
91679-37-7
| Molecular Weight: | 310.39 g./mol | Molecular Formula: | C₂₂H₁₈N₂ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD27982126 | |
| Melting Point: | >103 °C(dec.) | Boiling Point: | 529.4±29.0 °C(Predicted) |
| Density: | 1.151±0.06 g/cm3(Predicted) | Storage Condition: | Room temperature, seal, dry |
Product Description:
Used primarily as a key intermediate in the synthesis of antifungal medications, particularly in the production of imidazole-based antifungals such as ketoconazole and related derivatives. Its structure allows for effective interaction with fungal cytochrome P450 enzymes, inhibiting ergosterol biosynthesis, which is critical for fungal cell membrane integrity. Due to its lipophilic aromatic groups and imidazole ring, it enhances drug penetration into skin, nails, and mucosal tissues, making it valuable in topical and systemic antifungal formulations. Also employed in research for developing new antimicrobial agents and in medicinal chemistry for structure-activity relationship studies.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.025 G | 10-20 days | ฿25,330.00 |
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| 0.050 G | 10-20 days | ฿43,050.00 |
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4-([1,1'-Biphenyl]-4-yl(phenyl)methyl)-1H-imidazole
Used primarily as a key intermediate in the synthesis of antifungal medications, particularly in the production of imidazole-based antifungals such as ketoconazole and related derivatives. Its structure allows for effective interaction with fungal cytochrome P450 enzymes, inhibiting ergosterol biosynthesis, which is critical for fungal cell membrane integrity. Due to its lipophilic aromatic groups and imidazole ring, it enhances drug penetration into skin, nails, and mucosal tissues, making it valuable in topical and systemic antifungal formulations. Also employed in research for developing new antimicrobial agents and in medicinal chemistry for structure-activity relationship studies.
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