5-[3-(Hydroxymethyl)phenyl]-2H-tetrazole
95%
- Product Code: 196180
CAS:
179057-20-6
| Molecular Weight: | 176.18 g./mol | Molecular Formula: | C₈H₈N₄O |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD09864536 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | 2-8°C |
Product Description:
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as candesartan and azilsartan. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the AT1 receptor. Due to its polarity and ability to form hydrogen bonds, it improves the pharmacokinetic profile of the final drug, including solubility and metabolic stability. Also employed in medicinal chemistry research for developing new bioactive molecules targeting cardiovascular diseases.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 250mg | 10-20 days | ฿6,154.50 |
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| 1g | 10-20 days | ฿10,642.50 |
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| 5g | 10-20 days | ฿22,715.00 |
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5-[3-(Hydroxymethyl)phenyl]-2H-tetrazole
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as candesartan and azilsartan. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the AT1 receptor. Due to its polarity and ability to form hydrogen bonds, it improves the pharmacokinetic profile of the final drug, including solubility and metabolic stability. Also employed in medicinal chemistry research for developing new bioactive molecules targeting cardiovascular diseases.
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