9-(1-hydroxyethyl)-7-methyl-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one
98%
- Product Code: 197557
CAS:
1173900-35-0
| Molecular Weight: | 289.33 g./mol | Molecular Formula: | C₁₅H₁₉N₃O₃ |
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| EC Number: | MDL Number: | MFCD18206951 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | Room temperature |
Product Description:
Used primarily in research settings as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9. This compound plays a key role in studies related to transcription regulation, especially in cancer cell proliferation. By inhibiting CDK9, it disrupts the phosphorylation of RNA polymerase II, leading to reduced expression of short-lived oncoproteins such as Mcl-1, which are critical for tumor cell survival. As a result, it is widely used in oncology research to induce apoptosis in cancer cells, particularly in hematological malignancies like leukemia and lymphoma. Its morpholino and hydroxyethyl functional groups enhance solubility and target binding, making it a valuable tool compound in kinase inhibitor development and mechanistic studies of transcriptional control.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 100mg | 10-20 days | ฿25,740.00 |
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9-(1-hydroxyethyl)-7-methyl-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one
Used primarily in research settings as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9. This compound plays a key role in studies related to transcription regulation, especially in cancer cell proliferation. By inhibiting CDK9, it disrupts the phosphorylation of RNA polymerase II, leading to reduced expression of short-lived oncoproteins such as Mcl-1, which are critical for tumor cell survival. As a result, it is widely used in oncology research to induce apoptosis in cancer cells, particularly in hematological malignancies like leukemia and lymphoma. Its morpholino and hydroxyethyl functional groups enhance solubility and target binding, making it a valuable tool compound in kinase inhibitor development and mechanistic studies of transcriptional control.
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