ITD-1
10mM in DMSO
- Product Code: 198960
CAS:
1099644-42-4
| Molecular Weight: | 415.52 g./mol | Molecular Formula: | C₂₇H₂₉NO₃ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
ITD-1 is a small molecule inhibitor that selectively targets the TGFβ (transforming growth factor beta) signaling pathway, particularly by promoting the degradation of SMAD3, a key transcription factor in this pathway. It has been primarily investigated for its role in cardiac regeneration. By inhibiting TGFβ/SMAD3 signaling, ITD-1 helps reprogram fibroblasts into functional cardiomyocyte-like cells, offering potential for repairing heart tissue after injury such as myocardial infarction.
In research settings, ITD-1 has demonstrated the ability to enhance cardiac differentiation in stem cells and improve heart function in animal models by reducing fibrosis and promoting the formation of new muscle cells. Its application is mainly focused on regenerative medicine, especially in developing therapies for heart failure and other cardiovascular diseases where tissue repair is critical. Due to its reprogramming capabilities, ITD-1 is also used as a tool compound in studies exploring cellular plasticity and transdifferentiation.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿1,950.00 |
+
-
|
ITD-1
ITD-1 is a small molecule inhibitor that selectively targets the TGFβ (transforming growth factor beta) signaling pathway, particularly by promoting the degradation of SMAD3, a key transcription factor in this pathway. It has been primarily investigated for its role in cardiac regeneration. By inhibiting TGFβ/SMAD3 signaling, ITD-1 helps reprogram fibroblasts into functional cardiomyocyte-like cells, offering potential for repairing heart tissue after injury such as myocardial infarction.
In research settings, ITD-1 has demonstrated the ability to enhance cardiac differentiation in stem cells and improve heart function in animal models by reducing fibrosis and promoting the formation of new muscle cells. Its application is mainly focused on regenerative medicine, especially in developing therapies for heart failure and other cardiovascular diseases where tissue repair is critical. Due to its reprogramming capabilities, ITD-1 is also used as a tool compound in studies exploring cellular plasticity and transdifferentiation.
| Mechanism | - |
| Appearance | - |
| Longevity | - |
| Strength | - |
| Storage | - |
| Shelf Life | - |
| Allergen(s) | - |
| Dosage (Range) | - |
| Recommended Dosage | - |
| Dosage (Per Day) | - |
| Recommended Dosage (Per Day) | - |
| Mix Method | - |
| Heat Resistance | - |
| Stable in pH range | - |
| Solubility | - |
| Product Types | - |
| INCI | - |
Purchase History for
Loading purchase history...
Cart
No products
Subtotal:
฿0.00
฿0.00
Total :