Imidazole ketone erastin
10mM in DMSO
- Product Code: 199016
CAS:
1801530-11-9
| Molecular Weight: | 655.14 g./mol | Molecular Formula: | C₃₅H₃₅ClN₆O₅ |
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| Density: | Storage Condition: | -20°C |
Product Description:
Used in cancer research, particularly for studying ferroptosis—a form of regulated cell death driven by iron and lipid peroxidation. It acts as a potent and selective inhibitor of system Xc−, a cystine/glutamate antiporter critical for maintaining cellular redox balance. By blocking cystine uptake, it depletes glutathione levels and inactivates glutathione peroxidase 4 (GPX4), leading to lethal accumulation of lipid reactive oxygen species in cancer cells. Its selectivity makes it a valuable tool for probing ferroptosis pathways and evaluating therapeutic strategies in tumors resistant to apoptosis, especially in glioblastoma and other solid cancers.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | $286.10 |
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Imidazole ketone erastin
Used in cancer research, particularly for studying ferroptosis—a form of regulated cell death driven by iron and lipid peroxidation. It acts as a potent and selective inhibitor of system Xc−, a cystine/glutamate antiporter critical for maintaining cellular redox balance. By blocking cystine uptake, it depletes glutathione levels and inactivates glutathione peroxidase 4 (GPX4), leading to lethal accumulation of lipid reactive oxygen species in cancer cells. Its selectivity makes it a valuable tool for probing ferroptosis pathways and evaluating therapeutic strategies in tumors resistant to apoptosis, especially in glioblastoma and other solid cancers.
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