IU1-248
98%
- Product Code: 201222
CAS:
2307472-03-1
| Molecular Weight: | 337.42 g./mol | Molecular Formula: | C₂₀H₂₃N₃O₂ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | 2-8°C |
Product Description:
IU1-248 is a selective inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome. It is primarily used in research settings to study protein degradation pathways, particularly the ubiquitin-proteasome system. By inhibiting USP14, IU1-248 enhances the degradation of ubiquitinated proteins, making it a valuable tool for investigating cellular protein homeostasis.
It has been applied in studies related to neurodegenerative diseases, where accumulation of misfolded proteins is a key feature. Researchers use IU1-248 to explore how boosting proteasomal activity can clear toxic protein aggregates, such as tau or alpha-synuclein. It is also used in cancer research to examine how modulating proteasome function affects tumor cell survival and response to other therapies.
Due to its ability to fine-tune proteasome activity without fully blocking it, IU1-248 offers a more targeted approach compared to broad proteasome inhibitors, allowing for precise mechanistic studies in cell and animal models.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1mg | 10-20 days | $484.74 |
+
-
|
| 5mg | 10-20 days | $934.88 |
+
-
|
IU1-248
IU1-248 is a selective inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome. It is primarily used in research settings to study protein degradation pathways, particularly the ubiquitin-proteasome system. By inhibiting USP14, IU1-248 enhances the degradation of ubiquitinated proteins, making it a valuable tool for investigating cellular protein homeostasis.
It has been applied in studies related to neurodegenerative diseases, where accumulation of misfolded proteins is a key feature. Researchers use IU1-248 to explore how boosting proteasomal activity can clear toxic protein aggregates, such as tau or alpha-synuclein. It is also used in cancer research to examine how modulating proteasome function affects tumor cell survival and response to other therapies.
Due to its ability to fine-tune proteasome activity without fully blocking it, IU1-248 offers a more targeted approach compared to broad proteasome inhibitors, allowing for precise mechanistic studies in cell and animal models.
| Mechanism | - |
| Appearance | - |
| Longevity | - |
| Strength | - |
| Storage | - |
| Shelf Life | - |
| Allergen(s) | - |
| Dosage (Range) | - |
| Recommended Dosage | - |
| Dosage (Per Day) | - |
| Recommended Dosage (Per Day) | - |
| Mix Method | - |
| Heat Resistance | - |
| Stable in pH range | - |
| Solubility | - |
| Product Types | - |
| INCI | - |
Purchase History for
Loading purchase history...
Cart
No products
Subtotal:
$0.00
$0.00
Total :