JTE-607
10mM in DMSO
- Product Code: 201289
CAS:
188791-09-5
| Molecular Weight: | 597.36 g./mol | Molecular Formula: | C₂₅H₃₃Cl₄N₃O₅ |
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| Density: | Storage Condition: | -20°C |
Product Description:
JTE-607 is primarily investigated for its potential in treating hematological disorders, particularly leukemia. It functions as a selective inhibitor of the mixed lineage kinase (MLK) family, which plays a role in inflammatory signaling pathways and cell proliferation. By targeting MLK, JTE-607 modulates the JNK pathway, leading to reduced production of pro-inflammatory cytokines such as TNF-α and IL-1β. This mechanism is especially relevant in acute myeloid leukemia (AML), where dysregulated signaling contributes to uncontrolled cell growth. Studies show JTE-607 induces apoptosis in leukemia cells and suppresses tumor growth in preclinical models. Its anti-inflammatory and anti-leukemic properties make it a candidate for targeted cancer therapy, particularly in cases with limited response to conventional treatments. Research is ongoing to evaluate its efficacy and safety in clinical settings.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿6,920.00 |
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JTE-607
JTE-607 is primarily investigated for its potential in treating hematological disorders, particularly leukemia. It functions as a selective inhibitor of the mixed lineage kinase (MLK) family, which plays a role in inflammatory signaling pathways and cell proliferation. By targeting MLK, JTE-607 modulates the JNK pathway, leading to reduced production of pro-inflammatory cytokines such as TNF-α and IL-1β. This mechanism is especially relevant in acute myeloid leukemia (AML), where dysregulated signaling contributes to uncontrolled cell growth. Studies show JTE-607 induces apoptosis in leukemia cells and suppresses tumor growth in preclinical models. Its anti-inflammatory and anti-leukemic properties make it a candidate for targeted cancer therapy, particularly in cases with limited response to conventional treatments. Research is ongoing to evaluate its efficacy and safety in clinical settings.
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