L-685,458
10mM in DMSO
- Product Code: 201952
CAS:
292632-98-5
| Molecular Weight: | 672.85 g./mol | Molecular Formula: | C₃₉H₅₂N₄O₆ |
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| Density: | Storage Condition: | -20°C |
Product Description:
L-685,458 is primarily used in biochemical and pharmacological research as a potent and selective inhibitor of γ-secretase, an enzyme involved in the cleavage of amyloid precursor protein (APP). By inhibiting this enzyme, it reduces the production of amyloid-β peptides, which are implicated in the pathogenesis of Alzheimer’s disease. This makes L-685,458 a valuable tool in studying the mechanisms of amyloid formation and evaluating potential therapeutic strategies for neurodegenerative disorders. It is commonly applied in cell-based assays and animal models to assess γ-secretase modulation and its downstream effects on cellular signaling, particularly in the Notch pathway, which is also regulated by γ-secretase activity. Due to its high specificity and potency, it aids in distinguishing γ-secretase-related effects from other proteolytic processes in experimental settings.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿6,480.00 |
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L-685,458
L-685,458 is primarily used in biochemical and pharmacological research as a potent and selective inhibitor of γ-secretase, an enzyme involved in the cleavage of amyloid precursor protein (APP). By inhibiting this enzyme, it reduces the production of amyloid-β peptides, which are implicated in the pathogenesis of Alzheimer’s disease. This makes L-685,458 a valuable tool in studying the mechanisms of amyloid formation and evaluating potential therapeutic strategies for neurodegenerative disorders. It is commonly applied in cell-based assays and animal models to assess γ-secretase modulation and its downstream effects on cellular signaling, particularly in the Notch pathway, which is also regulated by γ-secretase activity. Due to its high specificity and potency, it aids in distinguishing γ-secretase-related effects from other proteolytic processes in experimental settings.
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