Mal-amide-PEG8-Val-Ala-PAB-PNP
99%
- Product Code: 203586
CAS:
2210247-59-7
| Molecular Weight: | 1033.08 g./mol | Molecular Formula: | C₄₈H₆₈N₆O₁₉ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
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| Density: | Storage Condition: | -20°C, Sealed |
Product Description:
Used in antibody-drug conjugates (ADCs) as a linker-payload system, enabling targeted delivery of cytotoxic agents to cancer cells. The Val-Ala dipeptide serves as a cleavable linker degraded by intracellular proteases, releasing the active drug. PAB-PNP acts as a self-immolative spacer that facilitates drug release upon cleavage. Mal-amide provides a site for conjugation to antibodies via thiol groups. PEG8 enhances solubility and reduces aggregation, improving pharmacokinetics and stability of the conjugate. Widely applied in oncology drug development for its precision and controlled release properties.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 25mg | 10-20 days | ฿79,210.00 |
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Mal-amide-PEG8-Val-Ala-PAB-PNP
Used in antibody-drug conjugates (ADCs) as a linker-payload system, enabling targeted delivery of cytotoxic agents to cancer cells. The Val-Ala dipeptide serves as a cleavable linker degraded by intracellular proteases, releasing the active drug. PAB-PNP acts as a self-immolative spacer that facilitates drug release upon cleavage. Mal-amide provides a site for conjugation to antibodies via thiol groups. PEG8 enhances solubility and reduces aggregation, improving pharmacokinetics and stability of the conjugate. Widely applied in oncology drug development for its precision and controlled release properties.
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