MC-PEG2-NH2
98%
- Product Code: 203587
CAS:
640267-62-5
| Molecular Weight: | 341.4 g./mol | Molecular Formula: | C₁₆H₂₇N₃O₅ |
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| Density: | Storage Condition: | -20°C, sealed, light-proof |
Product Description:
MC-PEG2-NH2 is widely used in bioconjugation and drug delivery applications due to its bifunctional structure. The maleimide (MC) group selectively reacts with thiol groups (-SH) in proteins, peptides, or other biomolecules, enabling site-specific coupling. The amine terminus (NH2) at the other end of the short PEG spacer allows for further modification with carboxylic acids or activated esters, facilitating the attachment of dyes, drugs, or targeting moieties.
Its short polyethylene glycol (PEG2) linker improves solubility in aqueous and polar solvents and helps reduce aggregation and non-specific binding. This makes MC-PEG2-NH2 particularly useful in the development of antibody-drug conjugates (ADCs), targeted therapies, and diagnostic probes.
Additionally, the compound is employed in surface functionalization of nanoparticles and biosensors, where controlled orientation and spacing of biomolecules are critical. The combination of reactivity, solubility, and molecular spacing makes it a valuable reagent in pharmaceutical research and bioconjugate chemistry.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 25mg | 10-20 days | $1,136.85 |
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MC-PEG2-NH2
MC-PEG2-NH2 is widely used in bioconjugation and drug delivery applications due to its bifunctional structure. The maleimide (MC) group selectively reacts with thiol groups (-SH) in proteins, peptides, or other biomolecules, enabling site-specific coupling. The amine terminus (NH2) at the other end of the short PEG spacer allows for further modification with carboxylic acids or activated esters, facilitating the attachment of dyes, drugs, or targeting moieties.
Its short polyethylene glycol (PEG2) linker improves solubility in aqueous and polar solvents and helps reduce aggregation and non-specific binding. This makes MC-PEG2-NH2 particularly useful in the development of antibody-drug conjugates (ADCs), targeted therapies, and diagnostic probes.
Additionally, the compound is employed in surface functionalization of nanoparticles and biosensors, where controlled orientation and spacing of biomolecules are critical. The combination of reactivity, solubility, and molecular spacing makes it a valuable reagent in pharmaceutical research and bioconjugate chemistry.
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