Mal-VC-PAB-PNP
95%
- Product Code: 203588
CAS:
1096584-62-1
| Molecular Weight: | 695.68 g./mol | Molecular Formula: | C₃₂H₃₇N₇O₁₁ |
|---|---|---|---|
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| Density: | Storage Condition: | -20°C |
Product Description:
Used in the development of antibody-drug conjugates (ADCs) as a cleavable linker that connects cytotoxic drugs to monoclonal antibodies. The linker system allows for controlled release of the drug inside target cells through enzymatic cleavage by cathepsin B in lysosomes. The PAB (para-aminobenzyl) spacer enables efficient drug release after cleavage, while the PNP group acts as a self-immolative unit. This design enhances the specificity and efficacy of ADCs in cancer therapy by minimizing off-target toxicity and improving plasma stability. Widely applied in oncology research and in the formulation of targeted therapeutics.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 10mg | 10-20 days | ฿38,750.00 |
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Mal-VC-PAB-PNP
Used in the development of antibody-drug conjugates (ADCs) as a cleavable linker that connects cytotoxic drugs to monoclonal antibodies. The linker system allows for controlled release of the drug inside target cells through enzymatic cleavage by cathepsin B in lysosomes. The PAB (para-aminobenzyl) spacer enables efficient drug release after cleavage, while the PNP group acts as a self-immolative unit. This design enhances the specificity and efficacy of ADCs in cancer therapy by minimizing off-target toxicity and improving plasma stability. Widely applied in oncology research and in the formulation of targeted therapeutics.
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