3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate
98%
- Product Code: 203592
CAS:
890409-87-7
| Molecular Weight: | 463.5 g./mol | Molecular Formula: | C₁₅H₁₇N₃O₈S₃ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD20226789 | |
| Melting Point: | Boiling Point: | 687.5±65.0 °C(Predicted) | |
| Density: | 1.59±0.1 g/cm3(Predicted) | Storage Condition: | -20°C |
Product Description:
Used as an intermediate in the synthesis of antibody-drug conjugates (ADCs), particularly in the development of targeted cancer therapies. It functions as a linker that connects cytotoxic agents to monoclonal antibodies, enabling selective delivery of the drug to tumor cells. The disulfide bond in its structure allows for controlled release of the payload inside the cell upon reduction in the intracellular environment. Its stability in circulation and efficient cleavage inside target cells make it valuable in improving the therapeutic index of ADCs. Also employed in bioconjugation research due to its reactive pyridyl disulfide group, which readily reacts with thiol-containing molecules under mild conditions.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 50mg | 10-20 days | £1,160.28 |
+
-
|
3-(Methylsulfonyl)-2,5-dioxopyrrolidin-1-yl 4-((5-nitropyridin-2-yl)disulfanyl)pentanoate
Used as an intermediate in the synthesis of antibody-drug conjugates (ADCs), particularly in the development of targeted cancer therapies. It functions as a linker that connects cytotoxic agents to monoclonal antibodies, enabling selective delivery of the drug to tumor cells. The disulfide bond in its structure allows for controlled release of the payload inside the cell upon reduction in the intracellular environment. Its stability in circulation and efficient cleavage inside target cells make it valuable in improving the therapeutic index of ADCs. Also employed in bioconjugation research due to its reactive pyridyl disulfide group, which readily reacts with thiol-containing molecules under mild conditions.
| Mechanism | - |
| Appearance | - |
| Longevity | - |
| Strength | - |
| Storage | - |
| Shelf Life | - |
| Allergen(s) | - |
| Dosage (Range) | - |
| Recommended Dosage | - |
| Dosage (Per Day) | - |
| Recommended Dosage (Per Day) | - |
| Mix Method | - |
| Heat Resistance | - |
| Stable in pH range | - |
| Solubility | - |
| Product Types | - |
| INCI | - |
Purchase History for
Loading purchase history...
Cart
No products
Subtotal:
£0.00
£0.00
Total :