Mal-PEG4-VC-PAB-DMEA
98%
- Product Code: 203593
CAS:
1569261-93-3
| Molecular Weight: | 892.01 g./mol | Molecular Formula: | C₄₁H₆₅N₉O₁₃ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD34469590 | |
| Melting Point: | Boiling Point: | 1098.9±65.0 °C(Predicted) | |
| Density: | 1.244±0.06 g/cm3(Predicted) | Storage Condition: | -20°C |
Product Description:
Used in antibody-drug conjugates (ADCs) as a cleavable linker-payload system. The valine-citrulline (VC) dipeptide enables selective release of the drug in the presence of cathepsin B, an enzyme overexpressed in tumor cells. The PAB (para-aminobenzylcarbamate) spacer facilitates efficient drug release upon cleavage. DMEA (dimethyl ethanolamine) acts as the cytotoxic payload, inducing cell death by disrupting cellular functions. The Mal-PEG4 component allows site-specific conjugation to thiol groups on antibodies, enhancing stability and pharmacokinetics. This construct improves therapeutic index by minimizing off-target toxicity and maximizing tumor-specific drug delivery.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 5mg | 10-20 days | ฿73,710.00 |
+
-
|
Mal-PEG4-VC-PAB-DMEA
Used in antibody-drug conjugates (ADCs) as a cleavable linker-payload system. The valine-citrulline (VC) dipeptide enables selective release of the drug in the presence of cathepsin B, an enzyme overexpressed in tumor cells. The PAB (para-aminobenzylcarbamate) spacer facilitates efficient drug release upon cleavage. DMEA (dimethyl ethanolamine) acts as the cytotoxic payload, inducing cell death by disrupting cellular functions. The Mal-PEG4 component allows site-specific conjugation to thiol groups on antibodies, enhancing stability and pharmacokinetics. This construct improves therapeutic index by minimizing off-target toxicity and maximizing tumor-specific drug delivery.
| Mechanism | - |
| Appearance | - |
| Longevity | - |
| Strength | - |
| Storage | - |
| Shelf Life | - |
| Allergen(s) | - |
| Dosage (Range) | - |
| Recommended Dosage | - |
| Dosage (Per Day) | - |
| Recommended Dosage (Per Day) | - |
| Mix Method | - |
| Heat Resistance | - |
| Stable in pH range | - |
| Solubility | - |
| Product Types | - |
| INCI | - |
Purchase History for
Loading purchase history...
Cart
No products
Subtotal:
฿0.00
฿0.00
Total :