Mal-PEG2-Val-Cit-PABA
98%
- Product Code: 203595
CAS:
1662687-83-3
| Molecular Weight: | 590.63 g./mol | Molecular Formula: | C₂₇H₃₈N₆O₉ |
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| EC Number: | MDL Number: | ||
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| Density: | Storage Condition: | -20°C |
Product Description:
Used in antibody-drug conjugates (ADCs) as a cleavable linker to connect cytotoxic drugs to monoclonal antibodies. The Val-Cil-PABA segment is a substrate for cathepsin B, an enzyme overexpressed in tumor cells, enabling targeted drug release inside cancer cells. Mal-PEG2 provides a maleimide group for stable conjugation to thiol groups on antibodies and introduces hydrophilic spacing to improve solubility and reduce aggregation. This linker system enhances the therapeutic index of ADCs by promoting selective drug activation in tumors while minimizing systemic toxicity.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 5mg | 10-20 days | ฿19,980.00 |
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Mal-PEG2-Val-Cit-PABA
Used in antibody-drug conjugates (ADCs) as a cleavable linker to connect cytotoxic drugs to monoclonal antibodies. The Val-Cil-PABA segment is a substrate for cathepsin B, an enzyme overexpressed in tumor cells, enabling targeted drug release inside cancer cells. Mal-PEG2 provides a maleimide group for stable conjugation to thiol groups on antibodies and introduces hydrophilic spacing to improve solubility and reduce aggregation. This linker system enhances the therapeutic index of ADCs by promoting selective drug activation in tumors while minimizing systemic toxicity.
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