Mal-amido-PEG8-val-gly-PAB-OH
98%
- Product Code: 203598
CAS:
2353409-52-4
| Molecular Weight: | 853.95 g./mol | Molecular Formula: | C₄₀H₆₃N₅O₁₅ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD31811439 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
Used in antibody-drug conjugates (ADCs) as a linker to connect cytotoxic drugs to monoclonal antibodies. The PEG8 spacer enhances solubility and flexibility, improving conjugation efficiency and stability in circulation. The val-gly dipeptide acts as a cleavable site by lysosomal enzymes, enabling targeted drug release inside cancer cells. The PAB (para-aminobenzyl alcohol) group serves as a self-immolative spacer, facilitating efficient release of the active drug after enzymatic cleavage. Mal-amido functionality allows site-specific conjugation to thiol groups on antibodies, ensuring controlled drug-to-antibody ratio and improved pharmacokinetics.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 5mg | 10-20 days | ฿118,420.00 |
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Mal-amido-PEG8-val-gly-PAB-OH
Used in antibody-drug conjugates (ADCs) as a linker to connect cytotoxic drugs to monoclonal antibodies. The PEG8 spacer enhances solubility and flexibility, improving conjugation efficiency and stability in circulation. The val-gly dipeptide acts as a cleavable site by lysosomal enzymes, enabling targeted drug release inside cancer cells. The PAB (para-aminobenzyl alcohol) group serves as a self-immolative spacer, facilitating efficient release of the active drug after enzymatic cleavage. Mal-amido functionality allows site-specific conjugation to thiol groups on antibodies, ensuring controlled drug-to-antibody ratio and improved pharmacokinetics.
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