Mal-amido-PEG2-Val-Cit-PAB-PNP
98%
- Product Code: 203974
Alias:
4-((2S,5S)-19-(2,5-dioxo-2,5-dihydro-1H-pyrrole-1-yl)-5-isopropyl4,7,17 Trioxo-2-(3-ureidopropyl)-10,13-dioxa3,6,16-triazadicanamide)benzyl (4-nitrophenyl)carbonate
CAS:
2112738-13-1
| Molecular Weight: | 854.86 g./mol | Molecular Formula: | C₃₉H₅₀N₈O₁₄ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD30828687 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
Used in antibody-drug conjugates (ADCs) as a cleavable linker to connect cytotoxic drugs to monoclonal antibodies. The Val-Cil-PAB segment is a substrate for cathepsin B, an enzyme overexpressed in tumor cells, enabling selective drug release inside cancer cells. The PNP (para-nitrophenol) acts as a self-immolative spacer that facilitates drug release upon enzymatic cleavage. The Mal-amido-PEG2 group provides a maleimide functionality for conjugation to thiol groups on antibodies and includes a short polyethylene glycol chain to improve solubility and stability of the conjugate. This linker system enhances the therapeutic index of ADCs by minimizing off-target toxicity and promoting targeted drug delivery.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 25mg | 10-20 days | ฿34,560.00 |
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Mal-amido-PEG2-Val-Cit-PAB-PNP
Used in antibody-drug conjugates (ADCs) as a cleavable linker to connect cytotoxic drugs to monoclonal antibodies. The Val-Cil-PAB segment is a substrate for cathepsin B, an enzyme overexpressed in tumor cells, enabling selective drug release inside cancer cells. The PNP (para-nitrophenol) acts as a self-immolative spacer that facilitates drug release upon enzymatic cleavage. The Mal-amido-PEG2 group provides a maleimide functionality for conjugation to thiol groups on antibodies and includes a short polyethylene glycol chain to improve solubility and stability of the conjugate. This linker system enhances the therapeutic index of ADCs by minimizing off-target toxicity and promoting targeted drug delivery.
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