Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate
10mM in DMSO
- Product Code: 204268
CAS:
159857-81-5
| Molecular Weight: | 737.75 g./mol | Molecular Formula: | C₃₅H₄₃N₇O₁₁ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | 171 °C(dec.) | Boiling Point: | |
| Density: | Storage Condition: | -20°C, avoiding light |
Product Description:
Used in antibody-drug conjugate (ADC) development as a linker-payload component. The maleimido group enables conjugation to cysteine residues on antibodies, while the dipeptide (valine-citrulline) acts as a cleavable spacer, selectively releasing the drug in the presence of intracellular enzymes like cathepsin B. The p-aminobenzyl alcohol moiety serves as a self-immolative linker, facilitating efficient drug release after enzymatic cleavage. The p-nitrophenyl carbonate group allows attachment of cytotoxic agents or reporter molecules. This compound is particularly valuable in targeted cancer therapies where controlled, site-specific drug release is critical.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿3,790.00 |
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Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate
Used in antibody-drug conjugate (ADC) development as a linker-payload component. The maleimido group enables conjugation to cysteine residues on antibodies, while the dipeptide (valine-citrulline) acts as a cleavable spacer, selectively releasing the drug in the presence of intracellular enzymes like cathepsin B. The p-aminobenzyl alcohol moiety serves as a self-immolative linker, facilitating efficient drug release after enzymatic cleavage. The p-nitrophenyl carbonate group allows attachment of cytotoxic agents or reporter molecules. This compound is particularly valuable in targeted cancer therapies where controlled, site-specific drug release is critical.
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