MLN2238
10mM in DMSO
- Product Code: 204383
CAS:
1072833-77-2
| Molecular Weight: | 361.03 g./mol | Molecular Formula: | C₁₄H₁₉BCl₂N₂O₄ |
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| Density: | Storage Condition: | -20°C |
Product Description:
MLN2238 is a selective proteasome inhibitor primarily used in cancer research, particularly for hematological malignancies such as multiple myeloma and lymphomas. It functions as an active metabolite of bortezomib, but with improved pharmacokinetic properties, allowing for better tissue penetration and sustained proteasome inhibition. Its main application lies in disrupting protein degradation pathways in cancer cells, leading to accumulation of misfolded proteins, endoplasmic reticulum stress, and ultimately apoptosis. Due to its targeted mechanism, MLN2238 has been investigated in clinical trials to evaluate its efficacy in relapsed or refractory cancers, especially where resistance to other proteasome inhibitors has developed. It is also used as a tool compound in preclinical studies to understand proteasome function and its role in tumor progression and immune response modulation.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿7,200.00 |
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MLN2238
MLN2238 is a selective proteasome inhibitor primarily used in cancer research, particularly for hematological malignancies such as multiple myeloma and lymphomas. It functions as an active metabolite of bortezomib, but with improved pharmacokinetic properties, allowing for better tissue penetration and sustained proteasome inhibition. Its main application lies in disrupting protein degradation pathways in cancer cells, leading to accumulation of misfolded proteins, endoplasmic reticulum stress, and ultimately apoptosis. Due to its targeted mechanism, MLN2238 has been investigated in clinical trials to evaluate its efficacy in relapsed or refractory cancers, especially where resistance to other proteasome inhibitors has developed. It is also used as a tool compound in preclinical studies to understand proteasome function and its role in tumor progression and immune response modulation.
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