MK-1064
10mM in DMSO
- Product Code: 204391
CAS:
1207253-08-4
| Molecular Weight: | 461.9 g./mol | Molecular Formula: | C₂₄H₂₀ClN₅O₃ |
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| Density: | Storage Condition: | -20°C |
Product Description:
MK-1064 is a potent and selective orexin receptor antagonist, specifically targeting the orexin 2 receptor (OX2R). It is primarily investigated for its role in treating insomnia and other sleep disorders by promoting sleep onset and maintenance. Unlike traditional sedative-hypnotics that broadly depress central nervous system activity, MK-1064 works by modulating the orexin system, which regulates wakefulness and sleep-wake transitions. This targeted mechanism may offer improved sleep quality with fewer side effects such as next-day drowsiness or cognitive impairment. It has been studied in clinical trials for its efficacy in adults with primary insomnia, showing promising results in increasing total sleep time and reducing wake after sleep onset. Due to its selectivity, MK-1064 represents a newer generation of sleep therapeutics aiming for better safety and tolerability profiles.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿7,200.00 |
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MK-1064
MK-1064 is a potent and selective orexin receptor antagonist, specifically targeting the orexin 2 receptor (OX2R). It is primarily investigated for its role in treating insomnia and other sleep disorders by promoting sleep onset and maintenance. Unlike traditional sedative-hypnotics that broadly depress central nervous system activity, MK-1064 works by modulating the orexin system, which regulates wakefulness and sleep-wake transitions. This targeted mechanism may offer improved sleep quality with fewer side effects such as next-day drowsiness or cognitive impairment. It has been studied in clinical trials for its efficacy in adults with primary insomnia, showing promising results in increasing total sleep time and reducing wake after sleep onset. Due to its selectivity, MK-1064 represents a newer generation of sleep therapeutics aiming for better safety and tolerability profiles.
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