MPEG-maleimide
MW 10000 Da
- Product Code: 204483
CAS:
99126-64-4
| Molecular Weight: | Molecular Formula: | CH₃O(C₂H₄O)n+₁-CH₂CH₂-C₄H₂NO₂ | |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00803681 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C, light-proof, inert gas |
Product Description:
MPEG-maleimide is widely used in bioconjugation for modifying proteins, peptides, and antibodies. Its maleimide group reacts selectively with thiol groups (-SH) on cysteine residues under mild conditions, forming stable thioether bonds. This makes it ideal for attaching polyethylene glycol (PEG) chains to biomolecules, a process known as PEGylation.
PEGylation improves the pharmacokinetic properties of therapeutic proteins by increasing their circulation half-life, reducing immunogenicity, and enhancing solubility and stability. MPEG-maleimide is especially useful when site-specific modification is required, as it targets cysteine residues, allowing for more controlled conjugation compared to non-selective PEGylation methods.
It is commonly used in the development of biopharmaceuticals, diagnostic probes, and targeted drug delivery systems. The PEG layer helps shield the active molecule from proteolytic degradation and rapid renal clearance. Additionally, MPEG-maleimide is employed in surface modification of nanoparticles and liposomes to improve biocompatibility and prolong in vivo circulation time.
Due to its reactivity and solubility, it is also used in crosslinking applications and hydrogel formation for biomedical engineering and controlled release formulations.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 250mg | 10-20 days | ฿3,140.00 |
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MPEG-maleimide
MPEG-maleimide is widely used in bioconjugation for modifying proteins, peptides, and antibodies. Its maleimide group reacts selectively with thiol groups (-SH) on cysteine residues under mild conditions, forming stable thioether bonds. This makes it ideal for attaching polyethylene glycol (PEG) chains to biomolecules, a process known as PEGylation.
PEGylation improves the pharmacokinetic properties of therapeutic proteins by increasing their circulation half-life, reducing immunogenicity, and enhancing solubility and stability. MPEG-maleimide is especially useful when site-specific modification is required, as it targets cysteine residues, allowing for more controlled conjugation compared to non-selective PEGylation methods.
It is commonly used in the development of biopharmaceuticals, diagnostic probes, and targeted drug delivery systems. The PEG layer helps shield the active molecule from proteolytic degradation and rapid renal clearance. Additionally, MPEG-maleimide is employed in surface modification of nanoparticles and liposomes to improve biocompatibility and prolong in vivo circulation time.
Due to its reactivity and solubility, it is also used in crosslinking applications and hydrogel formation for biomedical engineering and controlled release formulations.
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