Maleimide-C2-Amido-PEG4-Carboxylic Acid tert-Butyl Ester
≥98%(LC)
- Product Code: 209730
CAS:
1415800-35-9
| Molecular Weight: | 472.54 g./mol | Molecular Formula: | C₂₂H₃₆N₂O₉ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD22683312 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | Room temperature |
Product Description:
Used in bioconjugation for site-specific modification of peptides, proteins, and antibodies due to the maleimide group’s selective reaction with thiol groups (cysteine residues). The PEG4 spacer improves solubility and reduces aggregation, while the amide and carboxylic acid tert-butyl ester allow for further functionalization or controlled activation in multi-step synthesis. Commonly applied in the development of antibody-drug conjugates (ADCs), targeted therapies, and diagnostic probes where precise linkage and stability are critical. The tert-butyl ester acts as a protecting group, enabling selective deprotection under mild acidic conditions to reveal the carboxylic acid for subsequent coupling reactions.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 50mg | 10-20 days | ฿10,090.00 |
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Maleimide-C2-Amido-PEG4-Carboxylic Acid tert-Butyl Ester
Used in bioconjugation for site-specific modification of peptides, proteins, and antibodies due to the maleimide group’s selective reaction with thiol groups (cysteine residues). The PEG4 spacer improves solubility and reduces aggregation, while the amide and carboxylic acid tert-butyl ester allow for further functionalization or controlled activation in multi-step synthesis. Commonly applied in the development of antibody-drug conjugates (ADCs), targeted therapies, and diagnostic probes where precise linkage and stability are critical. The tert-butyl ester acts as a protecting group, enabling selective deprotection under mild acidic conditions to reveal the carboxylic acid for subsequent coupling reactions.
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