Mc-Val-Cit-PAB-Cl

95%

Product Code: 213990

CAS: 1639351-92-0

Molecular Weight:	Molecular Formula:	C₂₈H₃₉ClN₆O₆
EC Number:	MDL Number:
Melting Point:	Boiling Point:
Density:	Storage Condition:	-20°C

Product Description: Used primarily as a linker in antibody-drug conjugates (ADCs), enabling targeted delivery of cytotoxic agents to cancer cells. The dipeptide Mc-Val-Cit is cleavable by cathepsin B, an enzyme overexpressed in tumor tissues, allowing selective release of the active drug inside cancer cells. The PAB (para-aminobenzyl) spacer facilitates efficient drug release upon cleavage, while the chloro group (Cl) acts as a reactive handle for attachment to payloads such as maytansinoids or other cytotoxic agents. This linker system enhances the therapeutic index of ADCs by minimizing off-target toxicity and improving plasma stability.

Sizes / Availability / Pricing:

Size	Availability	Price	Quantity
100mg	10-20 days	฿200,000.00	+ -

Item	Document
Mc-Val-Cit-PAB-Cl	[Product Info] [Specification] [MSDS]

Mc-Val-Cit-PAB-Cl

Used primarily as a linker in antibody-drug conjugates (ADCs), enabling targeted delivery of cytotoxic agents to cancer cells. The dipeptide Mc-Val-Cit is cleavable by cathepsin B, an enzyme overexpressed in tumor tissues, allowing selective release of the active drug inside cancer cells. The PAB (para-aminobenzyl) spacer facilitates efficient drug release upon cleavage, while the chloro group (Cl) acts as a reactive handle for attachment to payloads such as maytansinoids or other cytotoxic agents. This linker system enhances the therapeutic index of ADCs by minimizing off-target toxicity and improving plasma stability.

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Mc-Val-Cit-PAB-Cl

95%

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