N-Succinimidyl-5-(2-pyridyldithio)valerate
98%
- Product Code: 214947
CAS:
317331-86-5
| Molecular Weight: | 340.42 g./mol | Molecular Formula: | C₁₄H₁₆N₂O₄S₂ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD26522028 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | 2-8°C |
Product Description:
Used in bioconjugation for creating stable linkages between proteins, antibodies, or peptides and other molecules such as drugs, labels, or solid supports. Its primary application is in the development of antibody-drug conjugates (ADCs), where it enables controlled attachment through thiol-disulfide exchange. The pyridyldithio group reacts selectively with free thiols, while the NHS ester end binds to primary amines on target biomolecules. This bifunctional reactivity allows for site-specific conjugation with measurable release kinetics due to the disulfide bond's sensitivity to reducing environments. Commonly used in diagnostic assays, targeted therapies, and protein labeling workflows where controlled, reversible linkage is required.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 5mg | 10-20 days | $184.68 |
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| 25mg | 10-20 days | $616.64 |
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N-Succinimidyl-5-(2-pyridyldithio)valerate
Used in bioconjugation for creating stable linkages between proteins, antibodies, or peptides and other molecules such as drugs, labels, or solid supports. Its primary application is in the development of antibody-drug conjugates (ADCs), where it enables controlled attachment through thiol-disulfide exchange. The pyridyldithio group reacts selectively with free thiols, while the NHS ester end binds to primary amines on target biomolecules. This bifunctional reactivity allows for site-specific conjugation with measurable release kinetics due to the disulfide bond's sensitivity to reducing environments. Commonly used in diagnostic assays, targeted therapies, and protein labeling workflows where controlled, reversible linkage is required.
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