Na-(((9H-Fluoren-9-yl)methoxy)carbonyl)-1-(2-(tert-butoxy)-2-oxoethyl)-L-tryptophan
98%
- Product Code: 215870
CAS:
1629658-33-8
| Molecular Weight: | 540.61 g./mol | Molecular Formula: | C₃₂H₃₂N₂O₆ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD32696725 | |
| Melting Point: | Boiling Point: | 747.9±60.0 °C(Predicted) | |
| Density: | 1.27±0.1 g/cm3(Predicted) | Storage Condition: | 2-8°C, sealed, dry |
Product Description:
Widely used in peptide synthesis, this compound serves as a protected amino acid derivative, enabling selective and efficient coupling reactions. The fluorenylmethyloxycarbonyl (Fmoc) group provides strong protection for the amine functionality, allowing it to remain stable during solid-phase synthesis while being easily removed under mild basic conditions. Its application is critical in the stepwise construction of complex peptides, especially in automated synthesizers.
The tert-butyl ester moiety protects the carboxylic acid group, offering orthogonal stability to acid-labile protecting groups, which allows for selective deprotection in multi-step sequences. This dual protection strategy makes the compound particularly useful in synthesizing tryptophan-containing peptides where side-chain reactivity must be controlled.
Due to the sensitivity of the indole ring in tryptophan to oxidation and electrophilic attack, the structure of this reagent helps minimize side reactions during elongation. It is therefore favored in the production of pharmaceutical peptides, bioactive molecules, and research-grade proteins requiring high purity and correct folding.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 | 10-20 days | £86.41 |
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| 0.250 | 10-20 days | £146.54 |
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| 1.000 | 10-20 days | £395.27 |
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Na-(((9H-Fluoren-9-yl)methoxy)carbonyl)-1-(2-(tert-butoxy)-2-oxoethyl)-L-tryptophan
Widely used in peptide synthesis, this compound serves as a protected amino acid derivative, enabling selective and efficient coupling reactions. The fluorenylmethyloxycarbonyl (Fmoc) group provides strong protection for the amine functionality, allowing it to remain stable during solid-phase synthesis while being easily removed under mild basic conditions. Its application is critical in the stepwise construction of complex peptides, especially in automated synthesizers.
The tert-butyl ester moiety protects the carboxylic acid group, offering orthogonal stability to acid-labile protecting groups, which allows for selective deprotection in multi-step sequences. This dual protection strategy makes the compound particularly useful in synthesizing tryptophan-containing peptides where side-chain reactivity must be controlled.
Due to the sensitivity of the indole ring in tryptophan to oxidation and electrophilic attack, the structure of this reagent helps minimize side reactions during elongation. It is therefore favored in the production of pharmaceutical peptides, bioactive molecules, and research-grade proteins requiring high purity and correct folding.
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