3,4,5-Trimethoxy-N-(3-(7-methylimidazo[1,2-a]pyridin-2-yl)phenyl)benzamide
98%
- Product Code: 215940
CAS:
708995-11-3
| Molecular Weight: | 417.46 g./mol | Molecular Formula: | C₂₄H₂₃N₃O₄ |
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| Density: | Storage Condition: | 2-8°C, sealed, dry |
Product Description:
Used in pharmaceutical research as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9, which plays a key role in transcription regulation. This compound shows promise in oncology for disrupting cancer cell proliferation by inhibiting RNA polymerase II phosphorylation, thereby suppressing the expression of anti-apoptotic proteins like Mcl-1. It is investigated for its antitumor activity in hematological malignancies, including leukemia and lymphoma. Its imidazopyridine core enhances binding affinity and selectivity, making it a valuable scaffold in developing targeted cancer therapies. Also employed as a chemical probe to study transcriptional control in cellular models.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 10mg | 10-20 days | ฿6,930.00 |
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| 25mg | 10-20 days | ฿13,860.00 |
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| 50mg | 10-20 days | ฿23,540.00 |
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3,4,5-Trimethoxy-N-(3-(7-methylimidazo[1,2-a]pyridin-2-yl)phenyl)benzamide
Used in pharmaceutical research as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9, which plays a key role in transcription regulation. This compound shows promise in oncology for disrupting cancer cell proliferation by inhibiting RNA polymerase II phosphorylation, thereby suppressing the expression of anti-apoptotic proteins like Mcl-1. It is investigated for its antitumor activity in hematological malignancies, including leukemia and lymphoma. Its imidazopyridine core enhances binding affinity and selectivity, making it a valuable scaffold in developing targeted cancer therapies. Also employed as a chemical probe to study transcriptional control in cellular models.
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