N6-Benzoyl-9-(2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)adenine 3'-CE phosphoramidite
≥95%
- Product Code: 216573
CAS:
2248740-48-7
| Molecular Weight: | 875.95 g./mol | Molecular Formula: | C₄₇H₅₁FN₇O₇P |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD15145363 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | Room temperature |
Product Description:
Widely used in oligonucleotide synthesis, this compound enables the incorporation of 2'-fluoro-modified RNA nucleotides into DNA strands. The modification enhances resistance to nuclease degradation, improving the stability of therapeutic oligonucleotides such as antisense agents, siRNA, and aptamers. The DMT (dimethoxytrityl) group allows for stepwise chain elongation with controlled coupling efficiency, while the phosphoramidite functionality ensures high reactivity during solid-phase synthesis. The N6-benzoyl protection stabilizes the adenine base during synthesis and is later removed under standard deprotection conditions. Its primary application lies in the production of modified nucleic acids for research, diagnostics, and development of nucleic acid-based drugs.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 25mg | 10-20 days | ฿13,590.00 |
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N6-Benzoyl-9-(2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)adenine 3'-CE phosphoramidite
Widely used in oligonucleotide synthesis, this compound enables the incorporation of 2'-fluoro-modified RNA nucleotides into DNA strands. The modification enhances resistance to nuclease degradation, improving the stability of therapeutic oligonucleotides such as antisense agents, siRNA, and aptamers. The DMT (dimethoxytrityl) group allows for stepwise chain elongation with controlled coupling efficiency, while the phosphoramidite functionality ensures high reactivity during solid-phase synthesis. The N6-benzoyl protection stabilizes the adenine base during synthesis and is later removed under standard deprotection conditions. Its primary application lies in the production of modified nucleic acids for research, diagnostics, and development of nucleic acid-based drugs.
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