N-Biotinyl-N'-(3-maleimidopropionyl)-3,6-dioxaoctane-1,8-diamine
90%
- Product Code: 217176
CAS:
305372-39-8
| Molecular Weight: | 525.6200 g./mol | Molecular Formula: | C₂₃H₃₅N₅O₇S |
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| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20 ℃ |
Product Description:
Used as a heterobifunctional crosslinking reagent in bioconjugation, this compound links biomolecules through its maleimide and amine-reactive functionalities. The maleimide group selectively reacts with thiol groups (–SH) in cysteine residues, while the amine-reactive end (typically NHS ester, if present in the active form) binds primary amines (–NH₂) in proteins or peptides. The PEG spacer (3,6-dioxaoctane) enhances solubility and increases the flexibility and accessibility of the linked molecules.
Commonly applied in the preparation of biotinylated proteins, antibodies, or peptides for detection, purification, or immobilization using streptavidin-based systems. Its use is prominent in immunoassays, targeted drug delivery, and surface coating in diagnostic platforms. The long, hydrophilic spacer arm reduces steric hindrance, improving binding efficiency to streptavidin. Also employed in proteomics and cell surface labeling where controlled, site-specific conjugation is required.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 50mg | 10-20 days | €76.28 |
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| 250mg | 10-20 days | €187.01 |
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| 1g | 10-20 days | €746.45 |
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N-Biotinyl-N'-(3-maleimidopropionyl)-3,6-dioxaoctane-1,8-diamine
Used as a heterobifunctional crosslinking reagent in bioconjugation, this compound links biomolecules through its maleimide and amine-reactive functionalities. The maleimide group selectively reacts with thiol groups (–SH) in cysteine residues, while the amine-reactive end (typically NHS ester, if present in the active form) binds primary amines (–NH₂) in proteins or peptides. The PEG spacer (3,6-dioxaoctane) enhances solubility and increases the flexibility and accessibility of the linked molecules.
Commonly applied in the preparation of biotinylated proteins, antibodies, or peptides for detection, purification, or immobilization using streptavidin-based systems. Its use is prominent in immunoassays, targeted drug delivery, and surface coating in diagnostic platforms. The long, hydrophilic spacer arm reduces steric hindrance, improving binding efficiency to streptavidin. Also employed in proteomics and cell surface labeling where controlled, site-specific conjugation is required.
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