N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide
≥98%
- Product Code: 217483
CAS:
90356-78-8
| Molecular Weight: | 398.37 g./mol | Molecular Formula: | C₁₈H₁₄F₄N₂O₂S |
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| Density: | Storage Condition: | Room temperature, dry |
Product Description:
Used as a key intermediate in the synthesis of Janus kinase (JAK) inhibitors, particularly in the development of pharmaceuticals targeting inflammatory and autoimmune diseases such as rheumatoid arthritis, psoriasis, and myelofibrosis. Its structure enables selective modulation of JAK enzyme activity, contributing to reduced cytokine signaling. It is employed in research and development for oral therapeutics due to its favorable binding properties and metabolic stability. Also utilized in structure-activity relationship (SAR) studies to optimize potency and selectivity in drug candidates.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
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| 1g | 10-20 days | $62.53 |
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| 25g | 10-20 days | $462.11 |
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| 100g | 10-20 days | $1,372.01 |
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| 5g | 10-20 days | $144.67 |
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N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide
Used as a key intermediate in the synthesis of Janus kinase (JAK) inhibitors, particularly in the development of pharmaceuticals targeting inflammatory and autoimmune diseases such as rheumatoid arthritis, psoriasis, and myelofibrosis. Its structure enables selective modulation of JAK enzyme activity, contributing to reduced cytokine signaling. It is employed in research and development for oral therapeutics due to its favorable binding properties and metabolic stability. Also utilized in structure-activity relationship (SAR) studies to optimize potency and selectivity in drug candidates.
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