2-((tert-butyldimethylsilyl)oxy)-N-methoxy-N-methylacetamide
95%
- Product Code: 219109
CAS:
163089-34-7
| Molecular Weight: | 233.38 g./mol | Molecular Formula: | C₁₀H₂₃NO₃Si |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD30471948 | |
| Melting Point: | Boiling Point: | ||
| Density: | 0.946±0.06 g/cm3(Predicted) | Storage Condition: | Room temperature, inert atmosphere |
Product Description:
Widely used in organic synthesis as a protected form of glycolic acid, enabling selective reactions in complex molecule assembly. Its silyl ether group provides stability under various reaction conditions while the N-methoxy-N-methyl amide (Weinreb amide) moiety allows controlled nucleophilic addition, especially in carbonyl-forming reactions. Commonly employed in multi-step syntheses of natural products and pharmaceuticals where chemoselectivity and functional group compatibility are critical. The compound facilitates the preparation of ketones from organometallic reagents due to the unique reactivity of the Weinreb amide. Its protecting group can be removed under mild acidic conditions, making it suitable for deprotection in sensitive substrates. Frequently used in peptide chemistry and macrolide synthesis for side-chain protection and controlled chain elongation.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1g | 10-20 days | ฿25,200.00 |
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2-((tert-butyldimethylsilyl)oxy)-N-methoxy-N-methylacetamide
Widely used in organic synthesis as a protected form of glycolic acid, enabling selective reactions in complex molecule assembly. Its silyl ether group provides stability under various reaction conditions while the N-methoxy-N-methyl amide (Weinreb amide) moiety allows controlled nucleophilic addition, especially in carbonyl-forming reactions. Commonly employed in multi-step syntheses of natural products and pharmaceuticals where chemoselectivity and functional group compatibility are critical. The compound facilitates the preparation of ketones from organometallic reagents due to the unique reactivity of the Weinreb amide. Its protecting group can be removed under mild acidic conditions, making it suitable for deprotection in sensitive substrates. Frequently used in peptide chemistry and macrolide synthesis for side-chain protection and controlled chain elongation.
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