mPEG-NHS
97%, average Mw5000
- Product Code: 223866
CAS:
135649-01-3
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| Density: | Storage Condition: | 2-8°C, light-proof, inert gas |
Product Description:
mPEG-NHS is widely used in bioconjugation to modify proteins, peptides, and other biomolecules. It reacts efficiently with primary amines (–NH₂) present on lysine residues or N-termini of proteins, forming stable amide bonds. This modification increases the solubility and stability of the biomolecules, reduces immunogenicity, and extends their circulation half-life in therapeutic applications.
It is commonly employed in the development of PEGylated drugs, where attaching polyethylene glycol helps improve pharmacokinetics and reduce rapid clearance from the body. mPEG-NHS is also used in surface modification of nanoparticles, hydrogels, and medical devices to create non-fouling surfaces that resist protein adsorption and cell adhesion.
In research, it serves as a blocking agent in protein studies and helps in the preparation of modified enzymes and antibodies for diagnostic and imaging applications. Its ability to introduce a methoxy-terminated PEG chain makes it ideal for creating well-defined, mono-functional conjugates.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 250mg | 10-20 days | ฿3,580.00 |
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| 1g | 10-20 days | ฿8,850.00 |
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mPEG-NHS
mPEG-NHS is widely used in bioconjugation to modify proteins, peptides, and other biomolecules. It reacts efficiently with primary amines (–NH₂) present on lysine residues or N-termini of proteins, forming stable amide bonds. This modification increases the solubility and stability of the biomolecules, reduces immunogenicity, and extends their circulation half-life in therapeutic applications.
It is commonly employed in the development of PEGylated drugs, where attaching polyethylene glycol helps improve pharmacokinetics and reduce rapid clearance from the body. mPEG-NHS is also used in surface modification of nanoparticles, hydrogels, and medical devices to create non-fouling surfaces that resist protein adsorption and cell adhesion.
In research, it serves as a blocking agent in protein studies and helps in the preparation of modified enzymes and antibodies for diagnostic and imaging applications. Its ability to introduce a methoxy-terminated PEG chain makes it ideal for creating well-defined, mono-functional conjugates.
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