PLX 5622, PLX-5622
10mM in DMSO
- Product Code: 223938
CAS:
1303420-67-8
| Molecular Weight: | 395.41 g./mol | Molecular Formula: | C₂₁H₁₉F₂N₅O |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
PLX-5622 is a selective inhibitor of the colony-stimulating factor 1 receptor (CSF1R), primarily used in research to deplete microglia, the resident immune cells of the central nervous system. It is widely applied in preclinical studies of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS to investigate the role of microglia in disease progression. By crossing the blood-brain barrier and effectively reducing microglial populations, PLX-5622 enables researchers to study neuroinflammation, synaptic changes, and neuronal health in the absence of microglial activity. It is also used in cancer research to examine the impact of tumor-associated macrophages on tumor growth and immune response, particularly in glioblastoma and other CNS malignancies. The compound is typically administered orally in rodent models and has become a valuable tool for understanding the contribution of myeloid cells in various disease contexts.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿9,980.00 |
+
-
|
PLX 5622, PLX-5622
PLX-5622 is a selective inhibitor of the colony-stimulating factor 1 receptor (CSF1R), primarily used in research to deplete microglia, the resident immune cells of the central nervous system. It is widely applied in preclinical studies of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS to investigate the role of microglia in disease progression. By crossing the blood-brain barrier and effectively reducing microglial populations, PLX-5622 enables researchers to study neuroinflammation, synaptic changes, and neuronal health in the absence of microglial activity. It is also used in cancer research to examine the impact of tumor-associated macrophages on tumor growth and immune response, particularly in glioblastoma and other CNS malignancies. The compound is typically administered orally in rodent models and has become a valuable tool for understanding the contribution of myeloid cells in various disease contexts.
| Mechanism | - |
| Appearance | - |
| Longevity | - |
| Strength | - |
| Storage | - |
| Shelf Life | - |
| Allergen(s) | - |
| Dosage (Range) | - |
| Recommended Dosage | - |
| Dosage (Per Day) | - |
| Recommended Dosage (Per Day) | - |
| Mix Method | - |
| Heat Resistance | - |
| Stable in pH range | - |
| Solubility | - |
| Product Types | - |
| INCI | - |
Purchase History for
Loading purchase history...
Cart
No products
Subtotal:
฿0.00
฿0.00
Total :