PIN1 inhibitor API-1
98%
- Product Code: 227093
CAS:
680622-70-2
| Molecular Weight: | 366.30 g./mol | Molecular Formula: | C₁₅H₁₃F₃N₆O₂ |
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| EC Number: | MDL Number: | ||
| Melting Point: | 208-211ºC | Boiling Point: | |
| Density: | Storage Condition: | -20°C, Sealed, Dry |
Product Description:
PIN1 inhibitor API-1 is primarily used in cancer research due to its ability to block the activity of the peptidyl-prolyl cis/trans isomerase Pin1 enzyme. This enzyme plays a critical role in regulating cell cycle progression and is often overexpressed in various cancers, including breast, prostate, and lung cancers. By inhibiting Pin1, API-1 disrupts oncogenic signaling pathways, leading to suppression of tumor cell proliferation and induction of apoptosis.
It has shown potential in enhancing the effectiveness of other anticancer agents, particularly in hormone-resistant cancers, by modulating key signaling molecules such as cyclin D1 and c-Myc. Additionally, API-1 is used as a research tool to study Pin1-dependent cellular processes, including transcription regulation and stress response. Its application supports the development of targeted therapies aimed at disrupting protein-protein interactions involved in cancer progression.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1mg | 10-20 days | $332.35 |
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| 5mg | 10-20 days | $934.88 |
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PIN1 inhibitor API-1
PIN1 inhibitor API-1 is primarily used in cancer research due to its ability to block the activity of the peptidyl-prolyl cis/trans isomerase Pin1 enzyme. This enzyme plays a critical role in regulating cell cycle progression and is often overexpressed in various cancers, including breast, prostate, and lung cancers. By inhibiting Pin1, API-1 disrupts oncogenic signaling pathways, leading to suppression of tumor cell proliferation and induction of apoptosis.
It has shown potential in enhancing the effectiveness of other anticancer agents, particularly in hormone-resistant cancers, by modulating key signaling molecules such as cyclin D1 and c-Myc. Additionally, API-1 is used as a research tool to study Pin1-dependent cellular processes, including transcription regulation and stress response. Its application supports the development of targeted therapies aimed at disrupting protein-protein interactions involved in cancer progression.
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