((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((S)-2-((4-((tert-Butoxycarbonyl)(methyl)amino)butyl)(methyl)amino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine
95%
- Product Code: 228699
CAS:
2375388-36-4
| Molecular Weight: | 917.23 g./mol | Molecular Formula: | C₄₉H₈₄N₆O₁₀ |
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| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C, Sealed, Dry |
Product Description:
This compound is a complex peptide-based molecule designed for use in targeted protein degradation, particularly as a PROTAC (Proteolysis Targeting Chimera). It functions by simultaneously binding to a specific disease-related protein and an E3 ubiquitin ligase, bringing them into proximity. This induces ubiquitination of the target protein, marking it for degradation by the cell’s proteasome system.
Its primary application is in research and development of therapeutics for diseases driven by hard-to-drug proteins, such as certain cancers and neurodegenerative disorders. Due to its high specificity and modular design, it enables selective degradation of pathogenic proteins without inhibiting their function, offering a powerful tool in chemical biology and drug discovery. It is used in vitro and in cellular assays to validate target proteins and assess degradation efficiency.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 50mg | 10-20 days | ฿33,730.00 |
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| 100mg | 10-20 days | ฿53,970.00 |
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((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((S)-2-((4-((tert-Butoxycarbonyl)(methyl)amino)butyl)(methyl)amino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine
This compound is a complex peptide-based molecule designed for use in targeted protein degradation, particularly as a PROTAC (Proteolysis Targeting Chimera). It functions by simultaneously binding to a specific disease-related protein and an E3 ubiquitin ligase, bringing them into proximity. This induces ubiquitination of the target protein, marking it for degradation by the cell’s proteasome system.
Its primary application is in research and development of therapeutics for diseases driven by hard-to-drug proteins, such as certain cancers and neurodegenerative disorders. Due to its high specificity and modular design, it enables selective degradation of pathogenic proteins without inhibiting their function, offering a powerful tool in chemical biology and drug discovery. It is used in vitro and in cellular assays to validate target proteins and assess degradation efficiency.
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