RI-1
10mM in DMSO
- Product Code: 229636
CAS:
415713-60-9
| Molecular Weight: | 361.61 g./mol | Molecular Formula: | C₁₄H₁₁Cl₃N₂O₃ |
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| Density: | Storage Condition: | -20°C |
Product Description:
RI-1 is a small molecule inhibitor that targets the RAD51 protein, which plays a key role in DNA repair through homologous recombination. Its primary application is in cancer research, particularly in studies focused on sensitizing tumor cells to DNA-damaging treatments such as chemotherapy and radiation. By inhibiting RAD51, RI-1 disrupts the repair of DNA double-strand breaks, making cancer cells more vulnerable to these therapies. It is especially studied in cancers with defects in other DNA repair pathways, such as BRCA-mutated tumors, where targeting backup repair mechanisms can lead to synthetic lethality. RI-1 serves as a valuable tool compound for exploring the role of homologous recombination in cellular responses to genotoxic stress and for developing new combination treatment strategies in oncology.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿7,200.00 |
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RI-1
RI-1 is a small molecule inhibitor that targets the RAD51 protein, which plays a key role in DNA repair through homologous recombination. Its primary application is in cancer research, particularly in studies focused on sensitizing tumor cells to DNA-damaging treatments such as chemotherapy and radiation. By inhibiting RAD51, RI-1 disrupts the repair of DNA double-strand breaks, making cancer cells more vulnerable to these therapies. It is especially studied in cancers with defects in other DNA repair pathways, such as BRCA-mutated tumors, where targeting backup repair mechanisms can lead to synthetic lethality. RI-1 serves as a valuable tool compound for exploring the role of homologous recombination in cellular responses to genotoxic stress and for developing new combination treatment strategies in oncology.
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