RPH-2823
≥99%
- Product Code: 230322
CAS:
96558-24-6
| Molecular Weight: | 370.41 g./mol | Molecular Formula: | C₁₇H₂₂N₈O₂ |
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| Density: | Storage Condition: | 2-8℃ |
Product Description:
RPH-2823 is a potent and selective inhibitor of the kinase enzyme TTK (also known as MPS1), which plays a critical role in the spindle assembly checkpoint during cell division. By inhibiting TTK, RPH-2823 disrupts proper chromosome segregation, leading to mitotic catastrophe and apoptosis in rapidly dividing cells, particularly cancer cells. This makes it a promising candidate for anticancer therapy, especially in tumors with chromosomal instability.
It has shown preclinical activity in various solid tumor models, including ovarian, breast, and lung cancers. RPH-2823 is being investigated for its ability to enhance the efficacy of other antimitotic agents and to overcome resistance to conventional chemotherapy. Its selectivity helps reduce off-target effects, improving the therapeutic window. Research is ongoing to evaluate its potential in combination therapies and its utility as a tool compound in studying mitotic mechanisms.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1mg | 10-20 days | $3,591.21 |
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RPH-2823
RPH-2823 is a potent and selective inhibitor of the kinase enzyme TTK (also known as MPS1), which plays a critical role in the spindle assembly checkpoint during cell division. By inhibiting TTK, RPH-2823 disrupts proper chromosome segregation, leading to mitotic catastrophe and apoptosis in rapidly dividing cells, particularly cancer cells. This makes it a promising candidate for anticancer therapy, especially in tumors with chromosomal instability.
It has shown preclinical activity in various solid tumor models, including ovarian, breast, and lung cancers. RPH-2823 is being investigated for its ability to enhance the efficacy of other antimitotic agents and to overcome resistance to conventional chemotherapy. Its selectivity helps reduce off-target effects, improving the therapeutic window. Research is ongoing to evaluate its potential in combination therapies and its utility as a tool compound in studying mitotic mechanisms.
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