Ro 48-8071
98%
- Product Code: 230388
CAS:
161582-11-2
| Molecular Weight: | 448.37 g./mol | Molecular Formula: | C₂₃H₂₇BrFNO₂ |
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| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | 2-8℃ |
Product Description:
Used primarily in biochemical and pharmacological research, this compound acts as a potent inhibitor of squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. By inhibiting this enzyme, it effectively reduces cholesterol production in cells, making it a valuable tool for studying lipid metabolism and developing potential treatments for hypercholesterolemia and related cardiovascular diseases. It has been utilized in in vitro and in vivo studies to explore the consequences of blocked cholesterol synthesis, including effects on cell membrane integrity, steroid hormone production, and liver function. Additionally, due to its ability to lower cholesterol without affecting coenzyme Q or dolichol synthesis, it offers a selective mechanism that helps researchers understand the specific roles of cholesterol in biological systems. Its application remains largely confined to preclinical research settings.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 5mg | 10-20 days | ฿4,890.00 |
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| 10mg | 10-20 days | ฿9,250.00 |
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| 50mg | 10-20 days | ฿43,210.00 |
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Ro 48-8071
Used primarily in biochemical and pharmacological research, this compound acts as a potent inhibitor of squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. By inhibiting this enzyme, it effectively reduces cholesterol production in cells, making it a valuable tool for studying lipid metabolism and developing potential treatments for hypercholesterolemia and related cardiovascular diseases. It has been utilized in in vitro and in vivo studies to explore the consequences of blocked cholesterol synthesis, including effects on cell membrane integrity, steroid hormone production, and liver function. Additionally, due to its ability to lower cholesterol without affecting coenzyme Q or dolichol synthesis, it offers a selective mechanism that helps researchers understand the specific roles of cholesterol in biological systems. Its application remains largely confined to preclinical research settings.
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