(S)-2-(2,6-Dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione
95%
- Product Code: 233473
CAS:
2357105-36-1
| Molecular Weight: | 274.23 g./mol | Molecular Formula: | C₁₃H₁₀N₂O₅ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | 568.3±45.0 °C(Predicted) | |
| Density: | 1.611±0.06 g/cm3(Predicted) | Storage Condition: | 2-8°C, Sealed, Inert Gas |
Product Description:
Used primarily in the pharmaceutical industry as an active pharmaceutical ingredient (API) intermediate for synthesizing immunomodulatory drugs. It plays a critical role in the production of targeted protein degraders, such as cereblon E3 ligase modulators, which are employed in the treatment of certain cancers, including multiple myeloma and myelodysplastic syndromes. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins. Due to its chiral center, the (S)-enantiomer exhibits higher biological activity and specificity compared to the racemic form, making it essential for developing potent and safer therapeutics. Also utilized in research settings for developing novel degrader molecules and studying ubiquitin-proteasome pathways.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 | 10-20 days | $376.49 |
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| 0.250 | 10-20 days | $677.69 |
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(S)-2-(2,6-Dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione
Used primarily in the pharmaceutical industry as an active pharmaceutical ingredient (API) intermediate for synthesizing immunomodulatory drugs. It plays a critical role in the production of targeted protein degraders, such as cereblon E3 ligase modulators, which are employed in the treatment of certain cancers, including multiple myeloma and myelodysplastic syndromes. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins. Due to its chiral center, the (S)-enantiomer exhibits higher biological activity and specificity compared to the racemic form, making it essential for developing potent and safer therapeutics. Also utilized in research settings for developing novel degrader molecules and studying ubiquitin-proteasome pathways.
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